產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | WR99210 |
規(guī)格 | 1mg、5mg |
貨號(hào) | EY-01Y10270 |
Cas No.: 47326-86-3
別名: N/A
化學(xué)名: N/A
分子式: C14H18Cl3N5O2
分子量: 394.68
溶解度: DMSO: 5 mg/mL (12.67 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of Plasmodium falciparum strains[2].IC50: <0.075 nM (DHFR)[1][1]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8.[2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.
特別提醒公司產(chǎn)品僅供科研使用
