產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | Tilmicosin-d3 |
規(guī)格 | 5 mg |
貨號(hào) | EY-01Y10314 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C46H77D3N2O13
分子量: 872.2
溶解度: Chloroform: slightly soluble,Methanol: slightly soluble
儲(chǔ)存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Tilmicosin-d3 is intended for use as an internal standard for the quantification of tilmicosin by GC- or LC-MS. Tilmicosin is a macrolide antibiotic.1 It is active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 μM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 μM), and inhibits bacterial protein synthesis (IC50 = 0.36 μM). Tilmicosin (75 mg/kg) increases serum creatine kinase (CK), the MB isoform of CK (CK-MB), and malondialdehyde (MDA) levels in mice, indicating cardiotoxicity.2 Formulations containing tilmicosin have been used in the treatment of respiratory diseases in sheep and cattle.1.Andersen, N.M., Poehlsgaard, J., Warrass, R., et al.Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolidesAntimicrob. Agents Chemother.56(11)6033-6036(2012)
2.Kart, A., Yapar, K., Karapehlivan, M., et al.The possible protective effect of ?-carnitine on tilmicosin-induced cardiotoxicity in miceJ. Vet. Med. A Physiol. Pathol. Clin. Med.54(3)144-146(2007)
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