產(chǎn)品屬性：
產(chǎn)品名稱 | Reduced Haloperidol |
規(guī)格 | 5mg、10mg、25mg、50mg |
貨號 | EY-01Y11387 |
Cas No.: 34104-67-1
別名: N/A
化學名: N/A
分子式: C21H25ClFNO2
分子量: 377.9
溶解度: Dichloromethane: slightly soluble,Methanol: slightly soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.
特別提醒公司產(chǎn)品僅供科研使用
