產(chǎn)品屬性：
產(chǎn)品名稱 | Polygalacin D |
規(guī)格 | 1mg、5mg |
貨號 | EY-01Y12452 |
Cas No.: 66663-91-0
別名: N/A
化學名: N/A
分子式: C57H92O27
分子量: 1209.32
溶解度: Soluble in DMSO
儲存條件: 4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]Polygalacin D (0-40 μM; 48 hours) inhibits cell proliferation with IC50s of 26.49 μM in the A549 cells and 20.52 μM in the H460 cells[1].Polygalacin D (0-20 μM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1].Polygalacin D (0-20 μM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1].Cell Proliferation Assay[1] Cell Line:A549 and H460 cancer cell lines[1]. Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr;39(4):1702-1710.
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