產(chǎn)品屬性：
產(chǎn)品名稱 | WRG-28 |
規(guī)格 | 1mg、5mg、10mg、25mg、50mg、100mg、200mg、500mg |
貨號(hào) | EY-01Y12789 |
Cas No.: 1913291-02-7
別名: N/A
化學(xué)名: N/A
分子式: C21H18N2O5S
分子量: 410.44
溶解度: DMSO: 15.62 mg/mL (38.06 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].[1]. Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794.
特別提醒公司產(chǎn)品僅供科研使用
