產(chǎn)品屬性：
產(chǎn)品名稱 | RORγt inverse agonist 13 |
規(guī)格 | 10mM*1 mL in DMSO、5 mg、10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y12852 |
Cas No.: 2170477-75-3
別名: N/A
化學名: N/A
分子式: C23H17Cl2F3N2O4
分子量: 513.29
溶解度: DMSO : 100 mg/mL (194.82 mM; Need ultrasonic)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM[1].RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3 μM in Th17 cell differentiation assay[1].RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1].[1]. Nannan Sun, et al. Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists. Eur J Med Chem. 2020 Jul 5;202:112536.
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