產(chǎn)品屬性：
產(chǎn)品名稱 | Salbutamol-d9 |
規(guī)格 | 500μg、1mg |
貨號 | EY-01Y13290 |
Cas No.: 1173021-73-2
別名: N/A
化學名: N/A
分子式: C13H12D9NO3
分子量: 248.4
溶解度: Methanol: Slightly Soluble,Water: Slightly Soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Salbutamol-d9 is intended for use as an internal standard for the quantification of salbutamol by GC- or LC-MS. Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).1 It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.2 It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).3 Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).References1. Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005).2. Cullum, V.A., Farmer, J.B., Jack, D., et al. Salbutamol: A new, selective β-adrenoceptive receptor stimulant. Br. J. Pharmacol. 35(1), 141-151 (1969).3. Arroyo, M.G., Cou?til, L.L., Nogradi, N., et al. Efficacy of inhaled levalbuterol compared to albuterol in horses with recurrent airway obstruction. J. Vet. Intern. Med. 30(4), 1333-1337 (2016).
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