產(chǎn)品屬性：
產(chǎn)品名稱 | Theaflavin 3,3'-digallate |
規(guī)格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y14343 |
Cas No.: 30462-35-2
別名: N/A
化學名: N/A
分子式: C43H32O20
分子量: 868.7
溶解度: DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml
儲存條件: Store at -20°C, sealed storage, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively). It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 μM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner.
特別提醒公司產(chǎn)品僅供科研使用
