產(chǎn)品屬性：
產(chǎn)品名稱 | Valdecoxib-d3 |
規(guī)格 | 1 mg、5 mg |
貨號 | EY-01Y17439 |
Cas No.: 1219794-90-7
別名: N/A
化學(xué)名: N/A
分子式: C16H11D3N2O3S
分子量: 317.4
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Valdecoxib-d3 is intended for use as an internal standard for the quantification of valdecoxib by GC- or LC-MS. Valdecoxib is a selective inhibitor of COX-2 (IC50s = 0.005 and 140 μM, for human recombinant COX-2 and COX-1, respectively).1 It decreases LPS-induced production of prostaglandin E2 in isolated human whole blood (IC50 = 0.89 μM). Valdecoxib reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED50s = 10.2 and 0.032 mg/kg, respectively). 1.Talley, J.J., Brown, D.L., Carter, J.S., et al.4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: A potent and selective inhibitor of COX-2J. Med. Chem.43(5)775-777(2000)
特別提醒公司產(chǎn)品僅供科研使用
